The drug should be used when prescribing physician. ASA may provoke bronchospasm and induce asthma attacks or other hypersensitivity reactions. Risk factors are the presence of a history of asthma, hay fever, nasal polyposis, chronic respiratory diseases and allergic reactions to other drugs (eg, skin reactions, pruritus, urticaria). ASA can cause bleeding of varying severity during and after surgery. The combination of ASA with anticoagulant, thrombolytic and antiplatelet drugs is accompanied by an increased risk of bleeding. ASA in low doses can trigger the development of gout in susceptible individuals (with a reduced excretion of uric acid). The combination of ASA with methotrexate is accompanied by an increased incidence of side effects of hematopoiesis.