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In mice, anxiolytic and sedative effects of to 1 g/kg extract of bitter orange were compared with chlordiazepoxide 10 mg/kg, valproic acid 400 mg/kg, or diazepam mg/kg. Mice were treated orally with 1 g/kg of the extract. After 30 minutes, each animal was injected with sodium pentobarbital 40 mg/kg. Sedative effects were measured in seconds by induction time (time from injection to loss of rightness reflex) and duration of sleep (time from loss of rightness reflex to awakening). The extract significantly increased the hypnotic effect of pentobarbital ( P < ). Several tests were used to examine the anxiolytic effect of the extract; however, the extract used in the elevated plus maze test produced an anxiolytic effect ( P < ). 4

In terms of molecular structure, synephrine has a phenethylamine skeleton, with a phenolic hydroxy - group, an alcoholic hydroxy- group, and an N -methylated amino -group. Alternatively, synephrine might be described as a phenylethanolamine with an N -methyl and p -hydroxy substituent. The amino-group confers basic properties on the molecule, whereas the phenolic –OH group is weakly acidic: the apparent (see original article for discussion) pK a s for protonated synephrine are (phenolic H) and (ammonium H). [52]

Use cautiously in patients with deficiency of spleen and stomach, or during pregnancy. Chih-ko ( zhiqiao ) To move qi; to ease the middle jiao and eliminate distention. Distention and pain in the epigastrium and abdomen and poor appetite due to stagnation of spleen and stomach qi. 3-10 grams Blue citrus ( qingpi ) To regulate liver and break qi; to disperse lumps and relieve stagnant food. Distending pain in the hypochondriac region and breast, hernia caused by stagnation of liver qi; distending pain in the abdomen and epigastrium due to stagnant food with stagnant qi; movable or immovable masses in the abdomen due to stagnation of qi and blood. 3-10 grams

Oxedrine 30mg

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