I went down to eating like 500 calories a day because I was so depressed, and between that, going off the Propecia, and my extreme stress and depression, my hair started shedding dramatically again. The only good news is that I finally lost the 15 pounds I’ve been trying to lose the last 5 years. The fact that I couldn’t lose weight until I nearly starved myself to death makes me think I really do have a thyroid problem, which could be making everything worse. I will soon be going to a doctor that does bio-identical hormone testing, which includes testing for thyroid issues, adrenal problems, and hormone imbalances. I’m starting to think my extreme stress has caused an adrenal problem (and maybe the running was too much for my body?), and I have had thyroid problems before that I have never able to treat successfully.
A key aspect of hair loss with age is the aging of the hair follicle.  Ordinarily, hair follicle renewal is maintained by the stem cells associated with each follicle. Aging of the hair follicle appears to be primed by a sustained cellular response to the DNA damage that accumulates in renewing stem cells during aging.  This damage response involves the proteolysis of type XVII collagen by neutrophil elastase in response to the DNA damage in the hair follicle stem cells. Proteolysis of collagen leads to elimination of the damaged cells and then to terminal hair follicle miniaturization.
Thanks for the information, dear sir i am around 29 years old i have hair loss problem and little lost my hair on bothe side of forhead, also i did treatment of my hair on India with injuction on my head that was good and regrew my hair, so after that i did PRP on my head with injuction on Afghanistan so i have hair problem again and my hair are very weak,sir i just want to treat my hair from falling i mean only to stop hair falling because i only lost little hair on my fogrhead sides the other hairs are fine. Please advise me that is much appreciated